Instructors:
Dr. Seyed-Ali Mortazavi, Developmental and Cell Biology, UCI
Dr. Kyoko Yokomori, Professor, Biological Chemistry, UCI School of Medicine
Prerequisites: High School Biology, Algebra II or Integrated Math II, and computer literacy
Course Description:
Genes manage all aspects of living organisms. While the genes in most cells in an organism are identical, cells can differ greatly in their morphology and function. This cluster will analyze genomes and focus on how different levels of gene expression help us differentiate between cells and organisms. The development and dystrophies of skeletal muscle will be used as a case study throughout. Through data analysis, labs, and computer modeling, students will have the opportunity to apply new sequencing technologies that are revolutionizing biology and medicine today.
Students will analyze gene expression using cutting-edge techniques such as RNA-seq. Students will practice their experimental design skills and analyze/measure gene expression through the study of skeletal muscle differentiation. Laboratory modules will include characterizing skeletal muscle differentiation, evaluating the efficiency of differentiation, measuring changes in gene expression changes using RNA-seq, and analyzing student RNA-seq data using computational tools and models. Students in small groups will design their own gene expression analysis projects and will conclude by presenting the results of their findings.